Drug Name

Sodium Lactate Ringer's Injection Instructions

Common Name: Sodium Lactate Ringer's Injection

Product Name:

English Name: Sodium Lactate Ringer's Injection

Chinese Pinyin: Rusuanna Linge Zhusheye

This product is a compound preparation, and its main components are: sodium lactate, sodium chloride, potassium chloride, calcium chloride CaCl2 · 2H2O per 1000ml;

Appearance: This product is a colorless and clear liquid;

Pharmacology and Toxicology: Under normal circumstances, the human body also has a small amount of lactic acid in the blood, mainly produced by glucose or glycogen fermentation, from muscles, skin, brain, and cells. After lactic acid is produced, it is either converted into glycogen or cupric acid, or enters the tricarboxylic acid cycle and is broken down into water and carbon dioxide. Therefore, the final metabolite of sodium lactate is sodium bicarbonate, which can correct metabolic acidosis; When hyperkalemia is accompanied by acidosis, sodium lactate can correct acidosis and allow potassium ions to enter the cell from the blood and extracellular fluid; The main organs for degrading lactate are the liver and kidneys. When lactate metabolism in the body is disrupted or obstructed, the therapeutic effect is not satisfactory;

The pH of pharmacokinetic sodium lactate is~, which is quickly absorbed after oral administration and metabolized into sodium bicarbonate within 1-2 hours through liver oxidation. However, intravenous injection is commonly used. Using sodium lactate instead of sodium acetate as a buffer in peritoneal dialysis fluid can reduce peritoneal irritation, inhibit cardiac function, and reduce peripheral vascular resistance;

Indications: Regulating body fluids, electrolytes, and acid-base balance drugs; Used for cases of metabolic acidosis or dehydration with metabolic acidosis;

Usage and dosage: Intravenous infusion of 500ml to 1000ml once for adults, with appropriate adjustments based on age, weight, and symptoms; Administration speed: 300-500ml per hour for adults;
Adverse reactions: ① Patients with hypocalcemia, such as uremia, are prone to symptoms such as numbness, pain, twitching, and difficulty breathing in the hands and feet after correcting acidosis, often caused by a decrease in blood hydrogen calcium ion concentration; ② Symptoms of pulmonary edema and heart failure such as accelerated heart rate, chest tightness, and shortness of breath; ③ Elevated blood pressure; ④ Weight gain and edema; ⑤ Alkalosis occurs when exceeding the limit; ⑥ Decreased blood potassium concentration, sometimes accompanied by hypokalemia;
Precautions: The following should be used with caution: ① The use of biguanides, especially Jiangtangling, by patients with diabetes hinders the use of lactic acid by the liver, which is likely to cause lactic acid poisoning; ② Edema patients with sodium retention tendency; ③ Hypertensive patients can increase their blood pressure; ④ Cardiac dysfunction; ⑤ When liver dysfunction occurs, the degradation rate of lactate slows down, resulting in a delay in the correction of acidosis; ⑥ Hypoxia and shock, insufficient blood supply to tissues, and slow metabolism of lactate oxidized to cupric acid entering the tricarboxylic acid cycle during hypoxia, resulting in a delay in the correction of acidosis; ⑦ Alcohol abuse, salicylic acid poisoning, and type I glycogen deposition disease have a tendency to cause lactic acidosis, and it is not advisable to use sodium lactate to correct acid-base balance; ⑧ Acetoacetic acid, β - hydroxybutyric acid and lactic acid increased in diabetes with copper acidosis, and often accompanied by poor circulation or organ blood supply insufficiency, and the degradation rate of lactic acid slowed down; ⑨ Kidney function is not complete, water and sodium retention is easy to occur, which increases cardiovascular load;
The following situations should be prohibited: ① heart failure and acute pulmonary edema; ② Cerebral edema; ③ When lactic acidosis has become significant; ④ Severe liver dysfunction; ⑤ Severe renal failure with oliguria or anuria;
The following tests and observations should be performed during medication: ① Blood pH and/or carbon dioxide binding capacity; ② Measurement of blood sodium, potassium, calcium, and chloride concentrations; ③ Renal function testing, including blood, muscle, liver, urea nitrogen, etc; ④ Blood pressure; ⑤ Cardiovascular and pulmonary function status, such as edema, shortness of breath, cyanosis, pulmonary rales, jugular vein filling, hepatic jugular venous reflux, etc., should be measured for venous pressure or central venous pressure as needed; ⑥ Symptoms of liver dysfunction include jaundice, altered consciousness, ascites, etc., which should be observed regularly before, after, and during the application of sodium lactate;
Pregnant and lactating women who use medication may experience exacerbation of edema and increased blood pressure in pregnant women with preeclampsia;

Calculate the dosage of medication for children based on age, weight, and condition;

Elderly patients often have hidden heart and kidney dysfunction when taking medication, and should be used with caution;

When drug interactions are combined with other drugs, it is important to note that drugs such as macrolide antibiotics, alkaloids, and sulfonamides may have compatibility contraindications due to changes in pH and ionic strength; Due to the presence of calcium ions in this product, it will precipitate when mixed with blood containing sodium citrate;

Excessive drug use may lead to edema or ion imbalance in the body;

Specification 500ml

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Storage sealed

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